一、实验室简介

浙江省神经老化与疾病研究重点实验室（Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research）由温州医科大学第一临床医学院执行院长兼附属第一医院副院长、脑科中心主任、神经外科主任医师诸葛启钏教授担任重点实验室主任。固定实验室研究成员42人，其中高级职称25人，博士13人。实验室位于温州医科大学附属第一医院新院门诊4号楼4楼，面积约3200平方。在科研仪器设备总值约3060 万元，实验室各种大小型设备均由专人管理。

 

二、主要研究方向

实验室针对我国老化与神经系统疾病诊治现状，以脑卒中的发病机制、防治技术研究，神经肿瘤与脑血管疾病基础与临床研究，神经变性疾病与系统神经科学研究为主要研究方向。

（1）脑卒中的发病机制各关键防治技术研究

A.出血性脑卒中大鼠 hNSCs 脑内移植后新生血管生成与运动功能恢复之机制研究和 VEGF 转基因 hESC神经干细胞脑出血大鼠脑内移植的血管生成机制研究；

B.出血性脑卒中的发病机制研究及关键干预技术研究；

C.缺血性脑卒中血管再通和血流动力学重构的关键技术研究；

D.中风后脑组织缺损的再生及组织工程支架研究；

E. 团队人员进一步研究4小时内血管内溶栓治疗缺血性脑卒中的静脉溶栓技术、栓子检测技术、人脑卒中和炎症反应机制等，进一步研究中国人神经衰老原因及防治体系。

（2）神经肿瘤与脑血管疾病基础与临床研究

在神经肿瘤方面：本团队深入开展神经肿瘤的基础与临床研究。

A.垂体腺瘤的发病机制及药物敏感性研究；

B.神经胶质瘤发病机制与防治研究；

C.神经肿瘤的精准外科技术研究；

在脑血管疾病方面：本团队继续对脑动静脉畸形形成机制的进行深入研究。

（3）神经变性疾病与系统神经科学研究。

包括：老年痴呆、帕金森病、神经心理性疾病等防治、大数据流行病学等研究。

三、实验室主要成员介绍

诸葛启钏：重点实验室主任

主任医师、教授、博士生导师，2000年享受国务院政府特殊津贴。现为温州医科大学第一临床医学、信息与工程学院院执行院长兼附属第一医院副院长、脑科中心主任。浙江省老化与神经疾病重点实验室主任，浙江省医学重点学科（显微神经外科学）负责人。目前还担任中国医师协会神经外科分会委员、脑血管病专家委员会委员、颅底外科专家委员会，中华医学会神经外科分会神经肿瘤学组委员、中国神经科学学会神经外科分会委员、中国抗癫痫协会理事；Aging and Disease杂志、中华神经外科杂志、中华神经外科杂志英文版和Neurosurgery中文版等编委，国家自然基金二审专家、国家科技部重大科技专项评审专家。

1987年7月毕业于温州医学院，1995年12月-1996年12月在首都医科大学北京天坛医院学习显微神经外科理论与技术，2008年12月-2009年12月 浙江大学管理学院高级工商管理班学习，2009年10月到12月在美国Arizona大学Barrow神经外科研究高级访问学者。

擅长显微神经外科技术和立体定向技术，目前主要从事颅底肿瘤微创外科技术和出血性脑血管病发病机制和关键技术研究。发表学术论文120多篇，其中SCI文章51篇，参编出版书5本，主译和主编著作各1本。负责国家和省部级以上课题9项，其中国家自然科学基金3项，浙江省科技厅重大专项和自然基金重点专项各1项；获得浙江省科技进步二等奖2项、三等奖2项，获得专利1项。

 

诸葛启钏

四、上级领导指导

实验室于2013年度召开第一学术委员会会议，周良辅院士对实验室研究方向和内容提出了意见和建议，健全了组织及管理机构，建立了规范完善的工作制度、管理制度、绩效考核和激励制度，初步形成了高效有序的运行机制 。

 

周良辅院士指导

重点实验室照片

 

五、实验室重要成果

（1）开放基金情况

1.项目名称：D5R介导的mTOR抑制诱导垂体腺瘤细胞发生自噬的机制研究，项目编号：LH017，起止年月：2015.01-2017.12，合同金额：2万元。

2.项目名称：携带tPA的磁性纳米棒靶向溶栓的特性研究，项目编号：LH018，起止年月：2014.01-2017.12，合同金额：5万元。

3.项目名称：多模态脑功能区高维可视化定位系统开发，项目编号：LH019，起止年月：2015.01-2017.12，合同金额：2万元。

（2）获得科技奖励情况

1）《脑胶质瘤免疫靶向治疗的研究》，获2015年度浙江省科学进步奖三等奖（郑伟明等人）。

2） 《垂体腺瘤的药物治疗研究》，获2013年度浙江省医药卫生科技奖一等奖，获2013年度浙江省科学技术进步奖二等奖（苏志鹏等人）。

（3）申请的专利

 

（4）发表论著情况

序号	论著题目	第一作者	出版社	出版时间
1	实验脑卒中手术学	金坤林	中国科学技术出版社	2012年12月
2	如何撰写和发表SCI期刊论文	金坤林	科学出版社	2010年1 月

 

（5）发表论文情况

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[2] Huang W, Li Q, Chen X, et al. Soluble Lectin-like Oxidized Low Density Lipoprotein Receptor-1 as A Novel Biomarker for Large-artery Atherosclerotic Stroke[J]. International Journal of Neuroscience, 2016 (just-accepted): 1-19.

[3] Xie R, Zhou K, Yuan J, et al. T2 relaxation time for intervertebral disc degeneration in patients with upper back pain: initial results on the clinical use of 3.0 Tesla MRI[J]. BMC Medical Imaging, 2017, 17(1): 9.

[4] Su Z, Chen Z, Wang B, et al. White blood cell count to mean platelet volume ratio (WMR) are positively correlated with disability in patients with myasthenia gravis (MG)[J]. Int J Clin Exp Med, 2017, 10(1): 889-896.

[5] Hu J, Huang W, Huang S, et al. Magnetically active Fe3O4 nanorods loaded with tissue plasminogen activator for enhanced thrombolysis[J]. Nano Research, 2016, 9(9): 2652-2661.

[6] Wu C, Ren W, Cheng J, et al. Association between serum levels of vitamin D and the risk of post-stroke anxiety[J]. Medicine, 2016, 95(18).

[7] Ren W, Tao J, Wei Y, et al. Time-Dependent Serum Brain-Derived Neurotrophic Factor Decline During Methamphetamine Withdrawal[J]. Medicine, 2016, 95(5).

[8] Lv D, Zhang M, Jin X, et al. The Body Mass Index, Blood Pressure, and Fasting Blood Glucose in Patients With Methamphetamine Dependence[J]. Medicine, 2016, 95(12).

[9] Ding S, Xu Z, Yang J, et al. The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy[J]. Molecular Neurobiology, 2016: 1-15.

[10] Zhu D H, Cai L, Wu Z B. A 12‐Year‐Old Male with Cerebral Peduncle Atrophy[J]. Brain Pathology, 2016, 26(3): 421-422.

[11] Liu M, Chen G, Fu Z, et al. Occult Mediastinal Yolk Sac Tumor Producing α-Fetoprotein Detected by 18F-FDG PET/CT[J]. Clinical nuclear medicine, 2016, 41(7): 585-586.

[12] Niu X, Wang X, Huang H, et al. Bulbocavernosus Reflex Test for Diagnosis of Pudendal Nerve Injury in Female Patients with Diabetic Neurogenic Bladder[J]. Aging and Disease, 2016, 7(6): 715.

[13] Gu Y, Zhao K, Luan X, et al. Association between Serum Magnesium Levels and Depression in Stroke Patients[J]. Aging and Disease, 2016, 7(6): 687.

[14] Saidan D, Jianjing Y, Xueli H, et al. Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy[J]. Aging and Disease, 0.

[15] Zhao B, Yang H, Zheng K, et al. Preoperative and postoperative predictors of long-term outcome after endovascular treatment of poor-grade aneurysmal subarachnoid hemorrhage[J]. Journal of Neurosurgery, 2016: 1-8.

[16] Yang J. The Multiple Roles of XBP1 in Regulation of Glucose and Lipid Metabolism[J]. Current Protein & Peptide Science, 2016, 17.

[17] Liu W, Chen X, Zhang Y. Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke[J]. American journal of translational research, 2016, 8(7): 3179.

[18] Lin C C, Shao B, Zhou Y L, et al. Maternal high-fat diet influences stroke outcome in adult rat offspring[J]. Journal of molecular endocrinology, 2016, 56(2): 101-112.

[19] Qian L, Yuanshao L, Wensi H, et al. Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke[J]. Aging and Disease, 2016, 7(5): 614.

[20] Tang Y, Wang L, Wang J, et al. Ischemia-induced Angiogenesis is Attenuated in Aged Rats[J]. Aging and Disease, 2016, 7(4): 326.

[21] Tu M, Wange W, Cai L, et al. IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway[J]. Tumor Biology, 2016, 37(11): 14701-14709.

[22] Zhao B, Tan X, Yang H, et al. Stent-assisted coiling versus coiling alone of poor-grade ruptured intracranial aneurysms: a multicenter study[J]. Journal of neurointerventional surgery, 2016: neurintsurg-2016-012259.

[23] Xu T, Lin B, Liu S, et al. Larger size ratio associated with the rupture of very small (≤ 3 mm) anterior communicating artery aneurysms[J]. Journal of neurointerventional surgery, 2016: neurintsurg-2016-012294.

[24] Fan L, Lin B, Xu T, et al. Predicting intraprocedural rupture and thrombus formation during coiling of ruptured anterior communicating artery aneurysms[J]. Journal of neurointerventional surgery, 2016: neurintsurg-2016-012335.

[25] He R Q, Zeng Q Y, Zhu P, et al. Risk of seizure relapse after antiepileptic drug withdrawal in adult patients with focal epilepsy[J]. Epilepsy & Behavior, 2016, 64: 233-238.

[26] Zhao B, Lin F, Wu J, et al. A Multicenter Analysis of Computed Tomography Angiography Alone Versus Digital Subtraction Angiography for the Surgical Treatment of Poor-Grade Aneurysmal Subarachnoid Hemorrhage[J]. World neurosurgery, 2016, 91: 106-111.

[27] Cai Z Y, Niu X T, Pan J, et al. The value of the bulbocavernosus reflex and pudendal nerve somatosensory evoked potentials in distinguishing between multiple system atrophy and Parkinson's disease at an early stage[J]. Acta Neurologica Scandinavica, 2016.

[28] Chen X L, Li Q, Huang W S, et al. Serum YKL‐40, a prognostic marker in patients with large‐artery atherosclerotic stroke[J]. Acta Neurologica Scandinavica, 2016.

[29] Zeng B, Zhu D, Su Z, et al. Tristetraprolin exerts tumor suppressive functions on the tumorigenesis of glioma by targeting IL-13[J]. International immunopharmacology, 2016, 39: 63-70.

[30] Wu Z R, Zhang Y, Cai L, et al. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup[J]. International Journal of Endocrinology, 2016, 2016.

[31] Tu M, Lu Q, Zhu P, et al. Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis[J]. Journal of the Neurological Sciences, 2016, 370: 258-262.

[32] Huang L, Ruan L, Nyanzu M, et al. Spontaneous resorption of giant serpentine aneurysm arising from middle cerebral artery[J]. Acta neurochirurgica, 2016, 158(11): 2063-2065.

[33] Xia W, Hou M. Macrophage migration inhibitory factor induces autophagy to resist hypoxia/serum deprivation‑induced apoptosis via the AMP‑activated protein kinase/mammalian target of rapamycin signaling pathway[J]. Molecular medicine reports, 2016, 13(3): 2619-2626.

[34] Xiong Y, Wang X M, Zhong M, et al. Alterations of caveolin‑1 expression in a mouse model of delayed cerebral vasospasm following subarachnoid hemorrhage[J]. Experimental and Therapeutic Medicine, 2016, 12(4): 1993-2002.

[35] Zhao B, Yang H, Zheng K, et al. Predictors of good functional outcomes and mortality in patients with severe rebleeding after aneurysmal subarachnoid hemorrhage[J]. Clinical neurology and neurosurgery, 2016, 144: 28-32.

[36] Fan L, Tan X, Xiong Y, et al. Stent-assisted coiling versus coiling alone of ruptured anterior communicating artery aneurysms: A single-center experience[J]. Clinical neurology and neurosurgery, 2016, 144: 96-100.

[37] Yu Z, Zhang Y, Liu N, et al. Roles of neuroglobin binding to mitochondrial complex III subunit cytochrome c1 in oxygen-glucose deprivation-induced neurotoxicity in primary neurons[J]. Molecular neurobiology, 2016, 53(5): 3249-3257.

[38] Yang J, Ding S, Huang W, et al. Interleukin-4 ameliorates the functional recovery of intracerebral hemorrhage through the alternative activation of microglia/macrophage[J]. Frontiers in neuroscience, 2016, 10.

[39] Zhao B, Tan X, Zhao Y, et al. Variation in patient characteristics and outcomes between early and delayed surgery in poor-grade aneurysmal subarachnoid hemorrhage[J]. Neurosurgery, 2016, 78(2): 224-231.

[40] Xia N, Liu Y, Zhong M, et al. Smoking associated with increased aneurysm size in patients with anterior communicating artery aneurysms[J]. World neurosurgery, 2016, 87: 155-161.

[41] Lin B, Chen W, Ruan L, et al. Sex differences in aneurysm morphologies and clinical outcomes in ruptured anterior communicating artery aneurysms: a retrospective study[J]. BMJ open, 2016, 6(4): e009920.

[42] Lin F, Wang S, Zhou Y, Wu C, Zou H, Geng P, et al. Pharmacokinetic interaction study combining lapatinib with vorinostat in rats. Pharmacology. 2015;95:160-5.IF=2.532

[43] Niu X, Wang X, Ni P, Huang H, Zhang Y, Lin Y, et al. Bulbocavernosus reflex and pudendal nerve somatosensory evoked potential are valuable for the diagnosis of cauda equina syndrome in male patients. International journal of clinical and experimental medicine. 2015;8:1162-7.IF=1.277

[44] Wang H, Shao B, Wang L, Ye Q. Fahr's disease in two siblings in a family: A case report. Experimental and therapeutic medicine. 2015;9:1931-3.IF=1.269

[45] Chen Y, Li ZF, Zhang FX, Li JX, Cai L, Zhuge QC, et al. Gamma knife surgery for patients with volumetric classification of nonfunctioning pituitary adenomas: a systematic review and meta-analysis. European journal of endocrinology / European Federation of Endocrine Societies. 2013;169:487-95.IF=4.069

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[47] Wu ZB, Cai L, Lin SJ, Lu JL, Yao Y, Zhou LF. The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. Brain research. 2013;1529:16-25.IF=2.43

[48] Ding S, Chen B, Zheng Y, Lu Q, Liu L, Zhuge QC. Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population.BMC psychiatry. 2013;13:107.IF=2.21

[49] Ding S, Liu L, Jing H, Xie J, Wang X, Mao J, et al. Dopamine from cirrhotic liver contributes to the impaired learning and memory ability of hippocampus in minimal hepatic encephalopathy. Hepatology international. 2013;7:923-36.IF=1.78

[50] Zheng W, ZhuGe Q, Zhong M, Chen G, Shao B, Wang H, et al. Neurogenesis in adult human brain after traumatic brain injury. Journal of neurotrauma. 2013;30:1872-80.IF=3.714

[51] Lou XH, Wu ZB, Zhang YZ. Bromocriptine-induced brainstem angulation in a patient with invasive prolactinoma.The Journal of clinical endocrinology and metabolism. 2013;98:867-8.IF=6.209

[52] ZhuGe Q, Wu Z, Huang L, Zhao B, Zhong M, Zheng W, et al. Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations. Journal of cellular and molecular medicine. 2013;17:1458-64.IF=4.014

[53] Li Q, Su Z, Liu J, Cai L, Lu J, Lin S, et al. Dopamine receptor D2S gene transfer improves the sensitivity of GH3 rat pituitary adenoma cells to bromocriptine. Molecular and cellular endocrinology. 2014;382:377-84.IF=4.405

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[55] Huang L, Wu ZB, Zhuge Q, Zheng W, Shao B, Wang B, et al. Glial scar formation occurs in the human brain after ischemic stroke. International journal of medical sciences. 2014;11:344-8.IF=2.862

[56] Ruan L, Lau BW, Wang J, Huang L, Zhuge Q, Wang B, et al. Neurogenesis in neurological and psychiatric diseases and brain injury: from bench to bedside. Progress in neurobiology. 2014;115:116-37.IF=9.992

[57] Lu Q, Gao L, Huang L, Ruan L, Yang J, Huang W, et al. Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat. Journal of neuroinflammation. 2014;11:44.IF=5.408

[58] Zhang H, Shao B, Zhuge Q, Wang P, Zheng C, Huang W, et al. Cross-talk between human neural stem/progenitor cells and peripheral blood mononuclear cells in an allogeneic co-culture model. PloS one. 2015;10:e0117432.IF=3.234

[59] Shao B, Zhou YL, Wang H, Lin YS. The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.Physiology & behavior. 2015;139:224-30.IF=2.976

[60] Zhu YB, Xia NG, Zhang YT, Wang XS, Liang SS, Yin WY, et al. Brain protection conferred by long-term administration of 2-(2-benzofuranyl)-2-imidazoline against experimental autoimmune encephalomyelitis. Neurochemical research. 2015;40:572-8.IF=2.593

[61] Wu AM, Ni WF, Huang ZY, Li QL, Wu JB, Xu HZ, et al. Analysis of differentially expressed lncRNAs in differentiation of bone marrow stem cells into neural cells. Journal of the neurological sciences. 2015;351:160-7. IF=2.474

[62] Su H, Tao J, Zhang J, Xie Y, Han B, Lu Y, et al. The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers. Comprehensive psychiatry. 2015;59:62-7.IF=2.252

[63] Wang T, Xi NN, Chen Y, Shang XF, Hu Q, Chen JF, et al. Chronic caffeine treatment protects against experimental autoimmune encephalomyelitis in mice: therapeutic window and receptor subtype mechanism. Neuropharmacology. 2014;86:203-11.IF=5.106

[64] Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, et al. Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke. CNS neuroscience & therapeutics. 2014;20:317-26.IF=3.931

[65] Ding S, Yang J, Liu L, Ye Y, Wang X, Hu J, et al. Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration. The international journal of biochemistry & cell biology. 2014;55:252-63.IF=4.046

[66] Han B, Lyu Y, Sun H, Wei Y, He J. Low serum levels of vitamin D are associated with post-stroke depression. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2014.IF=4.055

[67] Ding S, Hu J, Yang J, Liu L, Huang W, Gu X, et al. The inactivation of JAK2/STAT3 signaling and desensitization of M1 mAChR in minimal hepatic encephalopathy (MHE) and the protection of naringin against MHE. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2014;34:1933-50.IF=2.875

[68] Yang LH, Wang SL, Tang LL, Liu B, Ye WL, Wang LL, et al. Universal stem-loop primer method for screening and quantification of microRNA. PloS one. 2014;9:e115293. IF=3.234

[69] Zhang J, Xie Y, Su H, Tao J, Sun Y, Li L, et al. Prevalence and correlates of depressive symptoms during early methamphetamine withdrawal in Han Chinese population. Drug and alcohol dependence. 2014;142:191-6.IF=3.423

[70] Ni WF, Wu AM, Li QL, Huang ZY, Xu HZ, Yin LH. Induced human bone marrow stromal cells differentiate into neural cells by bFGF and cocultured with olfactory ensheathing cells. Current stem cell research & therapy. 2014;9:291-6.IF=2.212

[71] Wang XS, Fang HL, Chen Y, Liang SS, Zhu ZG, Zeng QY, et al. Idazoxan reduces blood-brain barrier damage during experimental autoimmune encephalomyelitis in mouse. European journal of pharmacology. 2014;736:70-6.IF=2.532

[72] Zhang Y, Chen WA. Biochanin A inhibits lipopolysaccharide-induced inflammatory cytokines and mediators production in BV2 microglia. Neurochemical research. 2015;40:165-71.IF=2.593

[73] Zhang J, Su H, Tao J, Xie Y, Sun Y, Li L, et al. Relationship of impulsivity and depression during early methamphetamine withdrawal in Han Chinese population. Addictive behaviors. 2015;43:7-10.IF=2.764

[74] Su H, Tao J, Zhang J, Xie Y, Sun Y, Li L, et al. An association between BDNF Val66Met polymorphism and impulsivity in methamphetamine abusers.Neuroscience letters. 2014;582:16-20.

[75] Zhang J, Zhang X, Su H, Tao J, Xie Y, Han B, et al. Increased serum brain-derived neurotrophic factor levels during opiate withdrawal. Neuroscience letters. 2014;571:61-5.IF=2.03

[76] Zhang Z, Xiao M, Ye Z, Zhang W, Han B, Li Y. Noncardiogenic stroke patients with metabolic syndrome have more border-zone infarction and intracranial artery stenosis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2015;24:629-34.IF=1.669

[77] Huang YY, Shao B, Ni XD, Li JC. Differential lesion patterns on T2-weighted magnetic resonance imaging and fluid-attenuated inversion recovery sequences in cryptogenic stroke patients with patent foramen ovale. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2014;23:1690-5.IF=1.669

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[79] Yang LH, Zheng FX, Chen Y, Jin YH, Zhang Z, Xie HX, et al. The significance of F139V mutation on thrombotic events in compound heterozygous and homozygous protein C deficiency. Blood coagulation &fibrinolysis : an international journal in haemostasis and thrombosis. 2014;25:824-30.IF=1.403

[80] Guo YJ, Liang DL, Xu ZS, Ye Q. In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. Die Pharmazie. 2014;69:367-70.IF=1.052

[81] Yang LH, Wang MS, Zheng FX, Li J, Chen Y, Jin YH, et al. Different impact of two mutations of a novel compound heterozygous protein C deficiency with late onset thrombosis. Genetics and molecular research : GMR. 2014;13:2969-77.IF=0.775

[82] Xu H, Ou F, Wang P, Naren M, Tu D, Zheng R. High dosage of agmatine alleviates pentylenetetrazole-induced chronic seizures in rats possibly by exerting an anticonvulsive effect. Experimental and therapeutic medicine. 2014;8:73-8.IF=1.269

[83] Niopas I, Daftsios AC, Nikolaidis N. Evaluation of the bioequivalence of two tablet formulations of enalapril/hydrochlorothiazide after single oral administration to healthy volunteers. Arzneimittel-Forschung. 2004;54:160-5.IF=

[84] Zhang L, Wen J, Pan Y, Li Z, Fan G, Wu Y. Determination of ulifloxacin, the active metabolite of prulifloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis. Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 2008;872:172-6.IF=2.729

[85] Han Z, Yang JL, Jiang SX, Hou ST, Zheng RY. Fast, non-competitive and reversible inhibition of NMDA-activated currents by 2-BFI confers neuroprotection. PloS one. 2013;8:e64894. IF=3.234

[86] He J, Xie Y, Tao J, Su H, Wu W, Zou S, et al. Gender differences in socio-demographic and clinical characteristics of methamphetamine inpatients in a Chinese population. Drug and alcohol dependence. 2013;130:94-100.IF=3.423

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[89] Ding S, Chen B, Zheng Y, Lu Q, Liu L, Zhuge QC. Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population.BMC psychiatry. 2013;13:107.IF=2.21

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（6）成果转让/转化情况

1）脑动脉瘤诊断后颅底动脉3D MS-CAT的解剖化特征及其数据库平台的构建

2）垂体腺瘤的药物治疗

3）CT灌注成像评价颈动脉支架植入术的疗效

 

六、具体联系方式

负责人：诸葛启钏

联系人：丁赛丹

联系电话：15888209333，

联系地址：浙江省温州市瓯海区上蔡村温州医科大学附属第一医院神经外科

联系邮箱：zhugeqichuan@vip.163.com

网址:http://ygb.wzhospital.cn:8015/wyyy_gzb/nksys/web/default.aspx?ksdm=309&type=wzsy